Telomerase, in other words, was revealed to be a key agent in longevity.In lab experiments, several critical markers of ageing in cells were "reset", including the size of telomeres."When I got to the point where I could see all the subunits - we had 11 proteins in total - it was a moment of &China Audi Q5 Medium Grille Factory39;Wow! Wow! This is how they all fit together'," said lead author Thi Hoang Duong Nguyen, a post-doc at UC Berkeley's Miller Institute for Basic Research in Science.

But early efforts to develop drugs that could control the enzyme's expression - essentially switching it on or off - "were hampered by an incomplete understanding of the structure and organisation of the telomerase complex," Stone added.A deficiency of the enzyme could accelerate cell death. It can also be linked to disease.Australian-American biologist Elizabeth Blackburn, who shared the 2009 Nobel Prize in Medicine for discovering telomeres and their protective function in the 1970s, likened them to the tiny plastic caps that keep shoelaces from fraying.A 2010 study showed that ageing could be reversed in mice that were treated with telomerase.In humans, each cell contains 23 pairs of chromosomes, including one pair of sex chromosomes - the "X" and "Y" - that differ between males and females. A 2010 study showed that ageing could be reversed in mice that were treated with telomerase.n 1985 Blackburn discovered telomerase, and its remarkable capacity to extend a cell's lifespan.

At the other extreme, too much telomerase "supports unbridled cell growth in most human cancers," he wrote in a commentary, also in Nature. (Photo: Pixabay) Elated scientists announced Wednesday (April 26) the completion of a 20-year quest to map the complex enzyme thought to forestall ageing by repairing the tips of chromosomes in plants and animals, including humans."Our findings provide a structural framework for understanding human telomerase disease mutations, and represent an important step towards telomerase-related clinical therapeutics. Its developers won the 2017 Nobel Prize in Chemistry.And in 2011, scientists found a way to transform age-worn cells from people over # 90 into rejuvenated stem cells indistinguishable from those found in embryos.To crack the telomerase code, Collins and her team used a state-of-the-art cryoelectron microscope (Cryo-EM) to see the enzyme in action at unprecedented resolutions of seven or eight angstroms.

But there is a twist.Cryo-EM can decipher the molecular structures of compounds that cannot be crystalized and imaged with X-rays.Decoding the architecture of the enzyme, called telomerase, could lead to drugs that slow or block the ageing process, along with new treatments for cancer, they reported in the journal Nature."Part protein and part RNA - genetic material that relays instructions for building proteins - telomerase acts on microscopic sheaths, known as telomeres, that cover the tips of the chromosomes found inside all cells.A 'WOW!' MOMENTIn 1985 Blackburn discovered telomerase, and its remarkable capacity to extend a cell's lifespan by essentially rebuilding telomeres with extra bits of DNA, much in the same way that retreading a tyre can make it nearly as good as new.

This, biologists agree, is probably central to the natural ageing process.An angstrom is one ten-billionth of a metre long."Inherited genetic mutations that compromise telomerase function cause disorders," said Michael Stone, a professor at the Center for Molecular Biology or RNA at the University of California, Santa Cruz."It has been a long time coming," lead investigator Kathleen Collins, a molecular biologist at the University of California in Berkeley, said in a statement.Eventually, however, shoelace tips and telomeres do break down: every time a cell divides the telomeres get worn a little bit more, until the cell stops dividing and dies

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You can also sprinkle poppy and sesame seeds when ariselus are hot so that they stick to it. Heat oil in a kadai and deep fry the ariselu on low flame till the colour changes to golden brown.Tip: These ariselus can be preserved for 2 to 3 days in an air tight container. Alternatively you can even roll it between two oiled plastic sheets and deep fry it.— Recipe by Umamaheshwari Mallela, home chefAriseluIngredients500 gm rice powder400 gm jaggeryOil for deep frying2 tbsp ghee2 tbsp sesame seeds2 tbsp poppy seedsMethodIn a pan, add jaggery and half cup water and boil till it becomes like a syrup.Let it simmer for ten minutes or oil surfaces. Once fermented, add besan and orange colour.After removing from ghee soak the jalebi in sugar syrup for a minute and serve hot. Mix well.Sprinkle black salt and pepper on the fried fafda and serve with hot jalebi and pickled chillies.

Knead it well.In a pan heat oil and add cloves, cinnamon, onions and green chillies. Add green chillies and sauté for a minute.Cool, mix and grind to a fine powder. If the batter is very thick, you can add some water. Now add tender tamarind leaves and salt.Add one cup water and ground spices and simmer on low heat till meat is tender and completely cooked.Now take small cherry sized balls of and press it into small puris. Leave this mixture for eight to 10 hours to ferment. Mix well and remove from the flame. Pressure cook the marinated mutton until it is tender and soft. Cover and let the leaves cook.Serve hot with rice. Podi Mamsumu Chinta Chiguru MamsamIngredients500 gm mutton2 tbsp ginger-garlic paste1 tbsp turmeric powderSalt to taste3-4 green chillies, slit½ cup tamarind leaves2 onions, chopped1 clove1 inch cinnamon1 tbsp red chilli powder3 tbsp oil1 tbsp garam masala powderSalt to tasteMethodMarinate mutton with ginger-garlic paste, turmeric powder and salt and keep for one hour.

Take a small lump of dough and drag it with the base of your palm.Mix curd, water and maida to form a thick paste. If the jalebi turns flat it means the batter is runny; add some more besan and fry again. When the syrup is done add ghee and sesame and poppy seeds.Dry roast red chillies, coriander seeds, green cardamoms, cinnamon, cloves, black peppercorns and poppy seeds one by one on a tawa over medium heat.Ruchika Sharma, celebrity chefPodi MamsumuIngredients500 gm mutton3 tbsp oil2 tsp saunf1 onion, finely sliced2 tbsp ginger-garlic paste8-10 red chillies½ cup curd2 China Cadillac Medium Grille Factory inch piece cinnamon4 green cardamoms2-4 cloves8-10 black peppercorns2 tsp khus khus1 tbsp coriander seeds3-4 green chillies, slit1 tsp turmeric powderSalt to tasteCoriander leavesMethodMarinate the mutton with curd, turmeric powder, ginger-garlic paste and salt for one hour.Marinate mutton with ginger-garlic paste, turmeric powder and salt and keep for one hour.Grease a clean surface.

Now add the cooked mutton, red chilli powder and garam masala powder.. Lift it up with a thin blade and deep fry. Fill this mixture in a icing bag or a sauce bottle with a long nozzle. Adjust water for gravy.Heat oil in a pan and sauté onions till golden brown.Continue cooking till all water dries up and oil surfaces.Sauté until onion changes colour. Garnish with coriander and serve hot with rice. Add the marinated mutton and sauté on high heat for two minutes.Tip: Use Guntur red chillies to get the authentic Andhra taste.Payal Valera, home chefJALEBIIngredients1 cup maida½ cup sour curdA few drops of orange colour1 tbsp besanGhee to deep fry for syrup1 cup sugarA few strands of saffronMethodMix sugar, water and saffron in a pan and allow it boil until it forms a one string thick syrup. Heat ghee in a kadai and drip the batter in circular shape like jalebi.Tip: This method is a little difficult and need practice.To this mixture add the rice flour and mix thoroughly.FafdaIngredients1 cup besan¼ tsp cooking sodaSalt to taste¼ tsp ajwainA pinch of turmeric powder1 tbsp oilOil to deep fryBlack Salt and pepper to tasteMethodMix besan, salt, cooking soda, ajwain, turmeric, oil and luke warm water to make a soft dough

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Only about 20 per cent of attendees this year are women; just two of the 15 keynote speakers at CES are female, as are only a quarter of the roughly 900 total speakers.From a distance, the mechanical humanoids on a strip-club stage looked something like real dancers in robot drag.”CES and womenYet critics point out that CES doesn’t do much else to create a positive environment for women. The robots served a racy but utilitarian function by drawing gawkers to the club, much the way provocatively clad "booth babes” lure CES visitors to wares on the convention floor."I see robotic strippers and I see half-naked women on the showroom floor promoting products,” said Ashleigh Giliberto, a CES attendee who works at a public-relations firm.CES itself has long had a boy’s club atmosphere.On one level, this was a classic Vegas stunt, a cheap way for the club to cash in on the presence of the world’s largest tech convention. Several prominent venture capitalists likewise left their firms following accusations that they’d made unwanted sexual overtures to female entrepreneurs.” Unsanctioned events, the statement said, aren’t reflective of CES "or the tech industry at large.Tania Yuki, CEO of the social analytics firm Shareablee and a speaker at CES, said she doesn’t think the show’s organizers are purposely sexist, just trapped in status-quo thinking that worked for years.

Sex and technology (and art)The robots are the work of artist Giles Walker, who made them seven years ago after he found two surveillance cameras on a warehouse floor.Uber co-founder Travis Kalanick was forced to step down as CEO after he fostered a startup culture rife with alleged sexual misconduct. CTA also says exhibitors must be "suitably dressed” and bans "inappropriate” displays, although it didn’t provide further details. "They’re paying my bills and giving me the chance to do other art that I do which is much less commercial and is much more underground. But those same officials have said they’re hamstrung by a policy that restricts keynote slots to company CEOs — most of whom are men.Executives from the Consumer Technology Association, which oversees CES, have promised to "redouble” efforts to add women’s voices to the speaker lineup next year. For instance, while the convention prohibits sexual harassment and other misbehaviour, it doesn’t lay out its policies in a formal code of conduct for attendees the way many other large tech gatherings do. (Photo: AP) On a recent evening in Las Vegas during the CES technology show, robot strippers offered a window into technology’s gender fault lines — not to mention our robot future.But they still provided some striking parallels to the much bigger tech show nearby.”

But his sexualised androids also point to a future in which robots might not just take on many jobs now held by people but are also likely to become companions — even intimate companions, a subject that squicks out many actual humans. But close up, they were clearly mannequins with surveillance-camera heads and abstractly sculpted feminine chests, buttocks and backs, shimmying and thrusting their boxy plastic hips. "It’s like, aren’t we worth more than that?”Technology and womenLast year was a watershed moment for women speaking out against sexism and sexual abuse, much of which reverberated through the tech industry. The robots are the work of artist Giles Walker, who made Chery Arrizo 5 Rear bumper Body Factory them seven years ago after he found two surveillance cameras on a warehouse floor.As robot technology advances, that future could get very weird very quickly. And they offered a glimpse of futurism crossed with sex, the sort of thing previously provided by the porn expo that used to overlap with the final days of CES. "I wanted to do a sculpture about voyeurism and the power between the voyeur and the person who’s being watched, ” he said. (CES policies do forbid the use of escort services, though.

Some of these robot companions are already here; high-end sexbots with ultra-realistic silicone "flesh” and artificial-intelligence personalities are available online for as much as 15,000. In a statement, organisers said they do not tolerate "inappropriate behaviour on our convention grounds or at official show events.. The dearth of female speakers and the presence of scantily clad show floor models are more "lazy” than "deliberately offensive,” she said. Their presence during the show reflects "a tone-deafness about women and gender within the industry,” said Elizabeth Ames, a senior vice president at the Anita Borg Institute, a nonprofit aimed at advancing women in the technology business.As robot technology advances, that future could get very weird very quickly. After all, the android dancers weren’t really strippers, since they wore no clothes; in fact, they were barely even robots, since they were tied to their poles and only capable of a limited set of motions.

The conference took pains to note that it has no affiliation with the strip club nor its temporary robot workers.Neither has it ever instructed attendees, participants and hosts "to not have booth babes, strippers, objectified, sexualized women as part of the ’entertainment,’” said Cindy Gallop, a former advertising executive turned sex-tech entrepreneur.)CES participants didn’t have to visit the club to come across the robots; images were prevalent in social media searches for CES-related posts.Walker acknowledged that bringing the robots to the strip club for an undisclosed fee has led the project astray from his initial vision. For instance, academics are already wrestling with the ethical implications of sexbots designed to look like children, not to mention practical questions such as whether they might deter actual paedophilia. "I’m not going to pretend,” he said

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Menstrual hygiene is important to ensure proper health to prevent unnecessarily infections and risk to health. Our aim is to reach out to the end consumers providing them with full knowledge and awareness on menstrual hygiene. Women under the age of 30 and not having any birthing experiences can opt for a small size while women over 30 or having given birth (normal or cesarean section) should opt for the large cup. It can also lead to urogenital infections (specifically Bacterial Vaginosis and UTI- Urinary Tract Infections).What does the brand do, on its part, to create more awareness on menstrual hygiene?We strive to raise awareness on menstrual hygiene through demonstrations and door-to-door meetings. This allows people to be able to be far more active in physical activities like swimming, cycling, running etc. The manufacturing of DEA Cup itself has minimal to no wastage. Assuming that the menstrual age lasts for 30 years, this number crosses a lakh of rupees.The brand, in its latest offering, intends to advocate reusable menstrual hygiene practices in the country. We have an enthusiastic and dedicated team who shares the passion for women empowerment. An Indian woman spends about Rs.Tell us a bit about the menstrual cups, what is so different about them?

A suitable alternative to sanitary product, the purpose of a menstrual cup is to collect the menstrual fluid and prevent the blood from leaking into clothes. It is a very significant issue and we address it with full concern trying to reach our to as many women as possible. The name "DEA” is inspired by my daughter’s name and through DEA Corp we are working on an awareness drive to break the taboo and the shackles of silence prevailing in the Indian society on menstruation.What are your views on menstrual hygiene? In India, it is observed that many women suffer from vaginal infections due to poor menstrual practices. Therefore it is much more cost effective and a better alternative to sanitary pads. The purpose of a menstrual cup is to collect the menstrual fluid and prevent the blood from leaking into clothes.It is different in the way of its insertion and its utilisation purpose. It is different from the other sanitary products because it collects the blood rather than absorbing the blood. Its durability is one of its most important aspects as one cup can be reused for 10 years. Cost efficient and with no risk of infection unlike pads and other products, DEA cups can be used for longer hours.9 billion pads per year.

The cup, shaped like a bell, is inserted inside the vagina during periods and sits quite low in the vagina.Amol Prakash Mane talks about how menstrual cup is different and adds to Swachh Bharat Abhiyan and Make in India campaign. Our team performs demonstrations to groups of young girls and ladies in the schools across cities. Lack of proper knowledge in disposal of used pads and unavailability of proper disposal methods are serious issues. Students are inquisitive learners, they have questions and doubts which they feel free to discuss, so school is the foundation where the seeds of knowledge can be germinated. It does not disturb any bodily functions.The advantages of using a menstrual cup is no risks of getting Toxic Shock Syndrome which one is likely to get for using the same tampon or pad for a long period of time.The cup adjusts as per the body shape and is perfect for use up to 12 hours in a day. A menstrual cup can be used up to 10 years. This way women can contribute towards environment and can be active participants of Swachh Bharat Abhiyan movement.How does the brand intend to contribute to the initiative of Swachh Bharat Abhiyan and Make in India campaign through the product?We intend to contribute to Swachh Bharat Abhiyan through providing an alternative menstrual hygiene product, that is the menstrual cup. Knowledge about different options of menstrual product is the essential.In a country where rampant act of sexual abuse and discord is prevalent, should not something be targeted towards the lower strata?

Should the product not be made accessible to a larger section of society?Indeed the product should me made available to a larger section and that is where we are heading to. The Menstrual cup is available in two sizes, namely, the small (Model -1)and the large sizes (Model-2). If a woman uses two pads per day during each period (approximately five days in a month), then the total number of pads used each year (by this group) would be 44. Small cup has a 41 mm diameter and large cup has 45 mm diameter.In conversation with this correspondent, Amol Prakash Mane, Founder, DEA Corp talks about why is it apt for athletes, fitness enthusiasts to young school and college going girls, how is it different and how the brand adds to the Swachh Bharat Abhiyan and Make in India campaign. (Photo: Pixabay) With a vision towards empowering today’s women with basic menstrual hygiene, DEA Corp recently launched its premium menstrual cups. Now imagine having to spend less than 1/100th of the cost when you use a menstrual cup. Disposal of sanitary pad is a huge problem in India. Poor hygiene adversely affects their health and there is an increased vulnerability to reproductive tract infections and other complications.

This is the time to convince women to move to biodegradable products that will help tackle the problem of disposable products that contain plasticWith China Mercedes-Benz ML-350 Grille DEA Menstrual Cups, we wish to spread awareness among school and college going girls and women starting with Vapi in Gujarat.6 per cent of Indian women use disposable napkins. We follow the REUSE (the DEA Cup) and REDUCE (wastage created by disposable menstrual products) cycle thoroughly. 300 per month in buying pads or tampons. Menstrual hygiene education has always been our main agenda in all the sessions that we have done so far in Vapi.. DEA Cup is a reusable menstrual cup made out of 100 per cent medical grade silicone. It also strives to make women active participants towards contributing to environment.What led you to the idea for them?The thought process behind DEA menstrual cup is to empower women by giving them an alternative product that can last as long as 10 years, thereby assisting them in saving money as well as to have a stress free and active life during periods. As per surveys, about 57

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When Prince Harry visits Nepal this weekend, ordinary people hope his tour of earthquake-hit areas will draw attention to the country’s struggle to recover from the 2015 disaster. Britain's Prince Harry (Photo: AP) When Prince Harry visits Nepal this weekend, ordinary people hope his tour of earthquake-hit areas will draw attention to the country’s struggle to recover from the 2015 disaster. "Hopefully when a big prince comes to these alleys and the world’s media will see how miserable our lives are, we will get some help,” said Ram Kaji, who was selling potatoes on the street near his damaged home in Patan, a historic district near the capital of Kathmandu.

The April 25, 2015, quake killed nearly 9,000 people, destroyed about one million homes and damaged many old temples, palaces and other structures in Patan and the capital.During his five-day trip, the 31-year-old will also visit a camp for displaced survivors and stay with a family whose men served in the Gurkha regiments of the British Army. "He has a huge amount of admiration for the resilience of the people of the country, particularly in response to the earthquakes last year,” Kensington Palace said in a statement.Harry is the first British royal to visit Nepal since the monarchy was abolished in 2008 following street protests.Since then, Nepal has turned into a republic, with a President chosen by a Parliament. The prince will meet with President Bidhya Devi Bhandari. Authorities have been slow to push ahead with rebuilding efforts. A government reconstruction agency was finally appointed in December but has yet to provide promised aid money to displaced families and guidelines to build new houses and structures.

People who live around the Golden Temple in Patan hope Harry’s visit will generate greater awareness about rebuilding needs.The Buddhist shrine that dates back 1,400 years was mostly spared by the earthquake but the adjoining monastery, prayer house and assembly halls have been damaged. Only plastic sheets are keeping the rain off and the damaged areas are closed to the public due to danger of collapse. Harry will also negotiate a narrow alley alongside brick and mud houses that are supported China Changan Automobile B pillar Body by wooden beams.Puspa Raj Bajracharya, who is on the committee that takes care of the Golden Temple, said they have sent requests and proposals to the government, saying it was getting dangerous for the devotees who come to the temple, but have not received any response. Repairs are estimated to cost about 25 million rupees (227,000), but so far only a fraction of that has been collected from private donors."His grandmother had visited the temple in the 1980s when she came to Nepal with her husband and now the young prince is coming,” Bajracharya said.

"We hope when the prince comes to our temple we will get the attention of the world to come help us.”Prince Harry will also travel to Bhaktapur, a historic town east of Kathmandu that suffered even more damage, and visit a nearby temporary camp for about 250 people made homeless by the disaster, a quarter of whom are children.In Pokhara, a lakeside town that is a base for trekkers in central Nepal, Harry will meet several retired Gurkha soldiers and their families. The prince served with a Gurkha battalion during a tour of duty in Afghanistan.The Gurkhas have served in the British army for 200 years and have a reputation for being brave, tenacious fighters. Thousands of young Nepali men attempt to pass the grueling test to become a Gurkha, but only a few get through.Harry will honor those killed in battle and spend a night with a local family.

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